Authors: Dr Babajide Jelili Olalekan
Department of Chemistry, Faculty of Science, University of Medical Sciences, Ondo City, Ondo state.
Most research on Terminalia catalpa, Delonix regia and Velvet tamarind plants were found to be directed towards the fruits and seeds without considering the high potential medicinal properties possessed by the barks and leaves of these plants. This work evaluates the antioxidant, antimicrobial, antimalarial, antiinflamatory and diuretics medicinal properties of the 3 plants stem barks and leaves using standard procedures. The powdered plant samples were screened for phytochemicals, using standard protocols. The result shows different level of antimicrobial activities against the microbes used. The highest zone of inhibition was observed at 45.67 mm for the ethanol extract of V. tamarind while S. aureus shows the lowest inhibition zone to the aqueous extract of T. catalpa with 6.33 mm in diameter. However, different minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) were obtained for different extracts. The methanolic extract of V. tamarind showed very high anti-plasmodial activity (IC50= 1.85 μg/ml) and high antioxidant activity as well. Other extracts shows different anti-plasmodial activities ranging from 2.10 to 4.63 μg/ml (chloroquine IC50= 8 μg/ml). High correlation between the different antioxidant assays was also observed. Only D. regia and V. tamarind leaves extracts shows significant anti-inflammatory and diuretic activity. The results showed significant anti -inflammatory activity at 300 mg/Kg when compared to that of diclofenac, one of the non-steroidal anti-inflammatory drugs. 150mg/kg ethanolic extract of T. catalpa leaves shows a significant increase urine output in the rats, confirming the diuretic property of the plant.
Key words: Terminalia catalpa, Delonix regia, Velvet tamarind, antioxidant, antimicrobial, antimalarial, antiinflamatory, diuretics